머리말

의사 국가고시를 준비하는 여러분 그리고 의과대학에서 의학을 공부하고 있는 여러분 모두에게 2026년대비 Pacific KMLE가 의지하고 볼 수 있는 책이 되기를 소망하며 글을 시작합니다.

여러분이 앞으로 치르게 될 의사 국가고시는 크게 실기시험과 필기시험으로 구성되어 있습니다.

우선, 실기시험은 매년 9월 초에 시작하여 약 2개월 동안 진행되며 수험생은 각자 지정된 시험일에 국시원을 방문하여 하루 동안에 모든 시험을 치르게 됩니다. 특히, 진료문항과 수기문항이 종합문항으로 합쳐진 융합형 시험 방식과 둘 이상의 주소로 접근해야 하는 복잡한 유형들도 출제되기 때문에 실기시험을 쉽게 생각하지 말고 열심히 준비하시기 바랍니다. Pacific KMLE에는 필기시험뿐만 아니라 실기시험에도 도움이 되는 내용들이 포함되어 있으니 실기시험을 공부하다가 필요한 지식이 있을 때 참고하여 보시면 좋겠습니다.

본 책의 주 목적인 필기시험은 보건의약관계법규, 의학총론, 의학각론 3개 과목으로 구성되어 있으며 이틀에 걸쳐 시험을 치르게 됩니다. 특히, 2025학년도 의사 국가고시 필기시험은 작년과 비슷한 문제 형식으로 멀티미디어 문항을 포함한 컴퓨터시험으로 출제되었습니다. 2022학년도부터 기존의 OMR 마킹을 이용한 지필시험이 아닌, 컴퓨터를 이용한 컴퓨터시험(CBT)으로 진행되는 점은 꼭 적응이 필요한 부분입니다. 국시원 홈페이지에서 바뀐 CBT 시스템을 체험해 볼 수 있으니 경험해보시면 좋겠습니다. 뿐만 아니라, 2026년 대비 Pacific KMLE도 전자책으로 출판되어 화면으로 문항과 영상자료를 학습할 수 있도록 적

응에 도움을 드리고 있습니다.

또한, 2022학년도 국시부터 출제문항 수의 축소와 함께 시행된 멀티미디어문항의 출제, 작년부터 없어진 R형 문제와 같이 문제 유형에도 많은 변화가 있었습니다. 출제문항 수 변화와 관련한 변화를 자세히 살펴보면, 의학각론 문제 수가 기존 280문항에서 240문항으로 축소되어 총 출제문항 수가 기존 360문항에서 320문항으로 축소되었고, 32문항씩 출제되던 R형 문제가 없어졌습니다. 시험 시간이 기존 5교시에서 4교시로 축소되었으나, 이에 따라 교시별 문항 수는 각 교시 당 80문항으로 증가(기존에는 각 교시 당 70문항, 1교시만 80문항 출제)하였습니다. 이를 고려하여 교시 별 시험시간은 각 교시 당 105분으로 확대(기존에는 각 교시 당 90분, 1교시만 100분)되었습니다.

또 다른 하나의 큰 변화인 멀티미디어문항은 ‘문항줄기(또는 답가지)에 텍스트와 함께 동영상, 소리 등 멀티미디어 자료를 포함한 문항’을 의미합니다. 컴퓨터시험(CBT)으로의 변화에 따라 이러한 멀티미디어 자료를 이용한 문항 출제가 가능해져 임상 증상과 신체 진찰 소견의 종합적인 이해가 필요합니다. 2022년도 3문제, 2023년도 6문제, 2024년도에 9문제, 2025년도에도 9문제가 출제되었으며 별도 공지가 없다면 올해와 마찬가지로 ‘2026학년도 제90회 의사 국가고시’ 필기시험에도 9문제 출제될 예정입니다. 난이도가 어렵지 않고 실기시험을 대비하면서 진단과 치료를 학습할 때 함께 공부하는 것도 도움이 되겠습니다.

교시 별로 살펴보면, 1교시에는 보건의약관계법규 20문제와 예방의학을 포함한 의학총론 60문제가 출제되며 나머지 교시들에는 의학각론 문제가 80문제씩 출제됩니다. 하지만 실제로 의학총론과 의학각론은 내용이 명확하게 구분되어 있지 않습니다. 멀티미디어문항은 다른 의학총론, 각론 문제들과 섞여서 나오며, 모든 교시에서 출제되었습니다. 필기시험의 경우에는 전 과목 총점 60% 이상(192문항), 각 과목 점수 40%(보건의약관계법규 8문항, 의학총론 24문항, 의학각론 96문항) 이상일 경우 합격입니다. 보건의약관계법규는 문제수가 적으니 각별히 주의해야 합니다.

2025년도 필기시험은 합격 요건을 충족하는 데에는 무리가 가지 않도록 이전 국시에서도 자주 출제되었던 평이한 난이도의 문제가 다수 출제되었습니다. 다만, 작년 시행되었던 2024년도 필기시험에서는 높은 난이도의 문제와 함께 생소한 개념들이 다수 출제되어 고득점을 얻기에는 어려운 구조로 출제되었습니다. 또한, 얕게 공부할 경우 헷갈리기 쉬운 개념 문제나 매력적인 오답이 많은 까다로운 문제들이 출제되었습니다. 올해는 난이도가 다수 평이했으나 국가고시 문제와 답안이 공개되면서 난이도가 전반적으로 높아지고 있는 추세이며, 환자가 호소하는 증상 및 징후, 제시된 검사 결과들을 종합적으로 판단해야 하는

증례 위주의 문제들이 다수 출제되었습니다. 더 나아가, 증례에서 제시된 질환에 대한 전형적인 검사나 치료법보다는 차선책으로 선택할 수 있는 처치와 2차 약제 등을 묻는 문제 역시 다수 출제되어, 꼼꼼히 공부하고 정리해 놓아야 풀 수 있는 문제들이 출제되고 있습니다. 다만, 그동안 생소한 개념이 출제되는 경우 임상의학종합평가에서 미리 신호를 주는 경우가 있었습니다.

2026년 대비 Pacific KMLE에서는 점차 변화해 가는 의사국가고시 유형에 맞게 문제를 편집하여 해설하였고 올해 새롭게 출제된 문제와 관련된 이론 부분을 강화하여, 앞으로 어떤 부분에서 어떤 유형의 문제가 나오더라도 여러분들이 쉽게 풀어낼 수 있도록 노력하였습니다. 특히, 전자책을 출간하면서 기존에 제공되던 개념 해설 및 문제 해설을 더 높은 가독성으로 제공할 수 있도록 편집하고 재구성하였습니다. 특히, 올해 출제된 문제 해설에 심화학습 해설 링크를 추가하여 최신 가이드라인부터 자세한 개념을 복습할 수 있도록 준비했습니다. 또한, 각 단원의 서두에 최근 국가고시 출제 경향 및 중요하게 다루어야 할 개념들에 대해 짤막한 언급을 실어 공부를 본격적으로 시작하기에 앞서 개략적인 내용을 파악할 수 있도록 하였습니다.

2026년 대비 Pacific KMLE는 최근 시험 경향의 분석을 통해 합격과 더불어 고득점을 원하시는 분들을 위해 다음과 같은 부분에 중점을 두고 개정하였습니다.

1. 국가고시 출제 유형이 변화함에 따라 점차 기존에 출제된 족보내용만 외우는 공부가 아닌, 전반적인 내용을 종합적으로 평가함으로써 적절한 검사 방법 및 치료를 떠올리고 선택하는 논리적 사고가 중요해지고 있습니다. 이에 따라 ‘이론학습 후 문제해결’ 순서를 유지하여 이론을 충분히 학습한 후 문제풀이를 통해 이를 적용해 보고 복습하면서 문제해결 능력을 다질 수 있도록 하였습니다.

또한 이론학습 부분의 질적인 향상을 위해 작년 의료법규 개정사항 및 앞으로 2025년도에 개정되고 시행될 사항, 예방의학 분야에서 업데이트된 통계정보 등 최신 지견을 반영하였습니다. 그리고 검사와 치료를 단순히 나열하는 방식에서 벗어나 특정 상황에서 어떠한 처치를 해야 하는지에 대한 기준을 명확하게 제시하기 위해 노력하였습니다. 추가적으로 국가고시 문제에서 사용되는 한글용어를 사용하여 실제 시험장에서 문제를 풀 때 의학용어 때문에 정답선택에 차질이 생기지 않도록 하였습니다.

2. 출제빈도와 임상적 중요성을 고려하여 ‘중요항목’을 반영하였습니다. 2016년도 국가고시부터 기본항목이 폐지되고 임상표현 중심의 평가목표가 제시되면서 기존에 출제되지 않았던 부분에서도 문제가 많이 출제되고 있습니다. 이에 각 파트의 앞부분에 출제경향과 중요사항을 제시하여 공부할 때 어떤 부분에 집중해야 하는지 파악할 수 있도록 하였고, 그동안 출제빈도가 낮았던 항목도 최근 국가고시의 출제 경향을 고려하여 ‘중요항목’으로 표시했습니다. ‘중요항목’을 완벽하게 숙지하고 시험장에 들어간다면 안전하게 합격을 노려볼 수 있을 것입니다.

3. 국가고시 출제 경향을 이해하고 중요한 부분에 더욱 집중할 수 있도록 기출문제에 A, B, C 분류를 적용하였습니다. 최근에 국가고시에 출제된 최신 경향이 반영된 문제를 A로 분류하였고, B와 C는 편집자의 재량에 따라 중요도와 출제 가능성을 고려하여 분류하였습니다. 최대한 효율적으로 공부할 수 있도록 최근 출제 경향에서 벗어나는 문제, 같은 내용이 반복되어 쉽게 풀리는 문제들은 삭제하였습니다. 각 단원에서 2025년도 의사국가고시와 관련된 문제는 문제번호에 색을 표시하였습니다. 필요한 경우에는 임종평 기출문제를 일부 추가하여 모의고사 대비에 있어서도 어려움이 없도록 하고자 하였습니다. 또한, 출제경향에 대한 감을 잡고 각 과별 내용을 복습하고 정리하는데 도움을 드리고자 R형 문제들은 뒷부분에 따로 묶어 놓았으니, R형 문제를 풀어보면서 공부한 내용들을 한 번 더 정리해 보기를 바랍니다.

4. 문제에 충실하고 통합적이며, 이해하기 쉬운 해설을 달기 위해 노력하였습니다. 또한 필요치 않게 긴 해설을 줄여 가독성을 높이되, 매력적인 오답에 한하여 최선의 답이 아닌 이유를 기술하여 비슷하지만 다른 문제가 출제되더라도 잘 대비할 수 있도록 준비하였습니다. 뿐만 아니라, 심화학습 해설을 추가하여 이해가 부족하거나 최신 가이드라인이나 진료 알고리즘을 전체적으로 참고하고 싶을 때 쉽게 찾아볼 수 있도록 준비했습니다.

마지막으로, 최신 문헌을 참고하여 문제에 대해 정확한 해설을 하기 위해 노력하였습니다(Harrison 제21판, Cecil 제27판, Sabiston 제21판, Schwartz 제11판, Nelson 제22판, Berek&Novak 제16판, Williams 제26판, Middleton’s Allergy 제9판, 산과학 제6판, 응급의학 제2판, 홍창의 소아과학 제12판, 부인과학 6판, 소화기계질환 4판, 최신정신의학 제6판, DSM-5, 신경정신의학 제3판, 신경과학 2판, 신경학 4판, 신경외과학 제4판, 이비인후과학 개정 2판(2018), 안과학 제13판, 피부과학 제7판, 의대생을 위한 피부과학 제5판, 비

뇨기과학 제5판, 2024 AHA guideline, 학생을 위한 정형의학 제4판, 예방의학과 공중보건학 제4판, 법제처 법률 원문 참고). 특히, 2022년에 Harrison, Williams와 2024년 Nelson 교과서가 개정되었으며, 이 교과서에서 확인된 변화를 모두 새롭게 정리하여 교재에 반영하였습니다.

위와 같은 기준에 의해 개정된 2026년 대비 Pacific KMLE가 의사국가고시를 준비하는 예비 의사 선생님들에게 시험의 길잡이가 될 수 있기를 바랍니다. 이 책에 나오는 지식을 시작으로 좋은 의사가 되어 예비 의사 선생님들의 앞날에 행복만이 가득하길 기원합니다.

퍼시픽 학술편찬국

건강증진, 의료윤리

건강증진 _17

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건강과 질병의 결정요인 ·············································································· 2 5

의료윤리 _28

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R-Type _49

역 학

서 론 _53

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질병발생의 역학적 개념 _56

질병 발생의 다요인설 ·················································································· 5 6

질병과 요인간의 원인적 연관성 ································································· 6 2

역학적 자료의 수집과 분류 _69

사망진단서 ···································································································· 6 9

역학 연구의 자료 ························································································· 8 1

질병 및 사망분포의 측정 _86

기술 역학의 세 가지 관찰 측면 ································································· 8 6

질병 빈도 측정의 종류 ················································································ 8 9

보건지표 측정방법 ······················································································· 9 2

발생률과 유병률과의 관계 ········································································· 1 0 1

건강 지표의 종류 ······················································································· 1 0 3

율의 표준화 ································································································ 1 1 0

바이어스 ······································································································ 1 1 8

타당도와 신뢰도 ························································································· 1 3 0

진단검사의 타당도를 나타내는 기준 ························································ 1 3 7

삶의 질 지표 ······························································································ 1 4 0

역학적 연구방법 _146

서론 ············································································································· 1 4 6

생태학적 연구 ····························································································· 1 5 1

단면조사연구 ······························································································· 1 5 5

환자?대조군 연구 ····················································································· 1 5 8

비차비(교차비, 환자군, 대조군 ·································································· 1 6 4

코호트 연구 ································································································ 1 6 8

비교위험도(상대위험도) ············································································· 1 7 6

실험역학 연구 ····························································································· 1 8 4

기타 연구 방법 ··························································································· 1 8 8

역학 연구의 새로운 분야 ·········································································· 1 9 4

질병의 역학적 특성과 관리 _195

우리나라 질병 양상의 변천내용 ······························································· 195

감염성 질병의 역학과 관리 _201

전염병 발생 모형과 개념 ·········································································· 2 0 1

집단 면역 ···································································································· 2 1 4

전염병 관리의 원칙 ··················································································· 2 1 9

비전염성 질환의 역학과 관리 _230

만성 비전염성 질환의 역학적 특성과 관리 ············································· 2 3 0

집단검진 ······································································································ 2 3 4

비전염성 질환의 역학과 관리 ··································································· 2 3 7

R-Type _246

환경 및 산업보건

서 론 _249

건강 위해성 평가 ······················································································· 2 4 9

환경오염 _255

환경오염 및 환경오염사건 ········································································· 2 5 5

대기오염 ······································································································ 2 6 1

대기오염에 의한 건강 장애 ······································································· 2 6 4

실내 공기 오염 ··························································································· 2 7 3

먹는물 관리와 수질 오염 ·········································································· 2 7 7

먹는물 주요 수질검사 항목 ······································································· 2 8 0

수질오염 ······································································································ 2 8 3

식품안전과 식중독 ····················································································· 2 8 5

산업보건 _287

산업재해의 원인 및 관리 ·········································································· 2 8 7

근로자 건강진단의 목적과 종류 ······························································· 289

산업재해보상보험 ······················································································· 2 9 1

재해 통계 지수 ··························································································· 2 9 3

산업재해 ······································································································ 2 9 6

산업중독 ······································································································ 2 9 9

직업성 질환 ································································································ 3 0 4

직업성 암 ···································································································· 3 0 8

직업성피부질환 ··························································································· 3 0 9

직업성 질환의 물리적 요인 _312

이상기온에 의한 장애?서론 ····································································· 3 1 2

고온 장애에 대한 예방 ·············································································· 3 1 3

고온 폭로에 의한 장애 ·············································································· 3 1 6

저온 환경에 의한 질환 ·············································································· 3 2 4

전리방사선 ·································································································· 3 2 8

비전리방사선 ······························································································· 3 3 1

소음성 난청 ································································································ 3 4 1

진동에 의한 신체장애 ················································································ 3 4 9

이상기압?저기압 ······················································································· 3 5 1

이상기압?고기압 ······················································································· 3 5 5

분진 ············································································································· 3 6 1

진폐증 ········································································································· 3 6 3

규폐증 ········································································································· 3 6 7

석면폐증 ······································································································ 3 7 2

기타 분진 ···································································································· 3 7 5

진폐증의 합병증 ························································································· 3 7 8

직업성 질환의 화학적 요인 _380

납(연) 중독 ································································································· 3 8 0

수은 중독과 미나마타병 ············································································ 3 8 6

카드뮴 중독 → 이타이이타이병 ······························································· 389

크롬 ············································································································· 3 9 3

비소 ············································································································· 3 9 5

망간 ············································································································· 3 9 8

베릴륨 ········································································································· 4 0 1

셀레늄 ········································································································· 4 0 3

알루미늄 ······································································································ 4 0 3

중금속과 직업병 ························································································· 4 0 6

유해가스 ······································································································ 4 0 9

유기용제?서론 ··························································································· 4 1 7

유기용제 ······································································································ 4 1 8

유기용제의 대사 ························································································· 4 2 6

내분비계 교란물질 ····················································································· 4 3 0

농약 ············································································································· 4 3 2

중독 ············································································································· 4 3 9

보건의료관리

보건의료 _447

보건의료?서론 ··························································································· 4 4 7

의료와 경제 ································································································ 4 4 8

바람직한 보건의료의 특성 ········································································· 4 4 9

보건의료체계의 개념과 목표 ····································································· 4 5 6

국가보건의료체계의 구성요소 ··································································· 4 5 6

보건의료체계의 시스템이론 ······································································· 4 6 1

보건의료체계의 분류 ·················································································· 4 6 4

보건의료 제공체계의 단계화와 지역화 ····················································· 4 6 6

우리나라의 보건의료체계 ··········································································· 4 7 2

보건의료 자원과 조직의 관리 _478

보건의료자원 ······························································································· 4 7 8

우리나라 보건의료자원의 현황 ································································· 4 7 9

의료인력에 관한 정책과 관리 ··································································· 4 8 4

집단개원 ······································································································ 4 8 6

의료기술 ······································································································ 4 8 6

병원관리?병원이란? ·················································································· 4 8 8

병원 조직의 특성 ······················································································· 4 9 1

병원관리의 지표 ························································································· 4 9 3

의료의 질의 구성요소 ················································································ 4 9 9

의료의 질 평가를 위한 접근 ····································································· 5 0 3

우리나라 의료의 질 관리 현황과 과제 ···················································· 5 0 6

의료보장 _511

사회보장과 의료보장 ·················································································· 5 1 1

국민건강보험의 현황 ·················································································· 5 1 9

우리나라 건강보험의 문제점 ····································································· 5 2 2

의료보험의 급여 ························································································· 5 2 3

의료급여제도(의료보호제도) ······································································ 5 2 4

진료비의 지불 방법(진료비 보상방식) ····················································· 5 2 7

의료비 관리 ································································································ 5 3 8

건강관련 행태와 의료이용 _542

건강관련 행태 ····························································································· 5 4 2

건강 행태?질병 예방 행위 ······································································ 5 4 4

질병행태의 정의 및 결정모형 ··································································· 5 5 2

환자 역할 행태와 치료순응도 ··································································· 5 5 6

의료이용에 영향을 미치는 요인 ······························································· 560

의료에 대한 필요, 요구, 수요 ·································································· 5 6 4

의료이용 연구모형?경제학적 수요 모형 ················································· 5 6 9

지역사회보건 _573

일차보건의료 ······························································································· 5 7 3

보건사업 ······································································································ 5 7 7

지역사회 보건사업의 기획 ········································································· 5 7 9

보건사업의 실제 _583

모성보건 ······································································································ 5 8 3

모성보건, 아동보건의 주요지표 ································································586

학교보건 ······································································································ 5 9 0

노인보건 ······································································································ 5 9 2

보건교육 ······································································································ 5 9 6

참고문헌 _598

찾아보기 _601